Sulfapyridine Detection: A Fast and Efficient Method Using Surface-Enhanced Raman Spectroscopy

Sulfapyridine is a widely used sulfonamide antibiotic that effectively prevents and treats animal diseases. It is known for its significant therapeutic effects and affordability \u005b104105\u005d. However, the slow metabolism of this antibiotic in animals can lead to its accumulation, and consumption of poultry meat containing antibiotic residues can pose a risk to human health \u005b106\u005d. China's "National Food Safety Standard for Maximum Residue Limits of Veterinary Drugs in Food" (GB 31650-2019) sets the maximum residue limit (MRL) for sulfonamide drugs in animal-derived food at 0.1 mg/kg. \n\nCurrently, the detection of Sulfapyridine residues commonly involves liquid chromatography, enzyme-linked immunosorbent assay, and fluorescence detection. However, these methods present several challenges such as complex pre-treatment procedures, lengthy detection times, high sample demands, and sample loss. Therefore, Surface-enhanced Raman spectroscopy offers a simple, rapid, and traceless alternative to detect Sulfapyridine at low concentrations.