Sulfapyridine Detection: A Simple and Rapid Approach using Surface-Enhanced Raman Spectroscopy

Revision: Sulfapyridine is a widely utilized sulfonamide antibiotic known for its effectiveness in preventing and treating animal diseases. It is not only cost-effective but also has a significant impact. However, the slow metabolism of this antibiotic in animals can lead to its accumulation, resulting in antibiotic residues in poultry meat consumed by humans. This, in turn, poses a risk to human health. In order to address this issue, China's "National Food Safety Standard for Maximum Residue Limits of Veterinary Drugs in Food" (GB 31650-2019) has established a maximum residue limit (MRL) of 0.1 mg/kg for sulfonamide drugs in animal-derived food.\n\nCurrently, the most commonly used methods for detecting sulfapyridine residues include liquid chromatography, enzyme-linked immunosorbent assay, and fluorescence detection. However, these methods are plagued by several issues such as complex pre-treatment operations, lengthy detection times, a high demand for samples, and the potential loss of samples. To overcome these challenges, surface-enhanced Raman spectroscopy offers a simple, rapid, and traceless approach to detect sulfapyridine at low concentrations.