Autophagy's Role in Oral Tissue Regeneration: Mechanisms and Therapeutic Potential

This review specifically focuses on autophagy's role in regulating stem cells and promoting oral tissue regeneration. We discuss how autophagy machinery operates within the cell, helping oral stem cells cope with survival stress. Additionally, we explore the molecular mechanisms involved in autophagy-mediated oral tissue regeneration, highlighting potential approaches for regulating autophagy using small molecule drugs, biomaterials, exosomes/RNAs, and other targeted treatments.

Despite significant progress in understanding the role of autophagy in oral tissue regeneration, many questions remain unanswered. Further mechanistic studies are necessary to fully elucidate the exact mechanisms by which autophagy contributes to tissue regeneration, and to develop effective therapeutic interventions.

In summary, this review provides new insights into the complex interplay between autophagy and oral tissue regeneration, and may serve as a useful resource for researchers exploring the potential of autophagy manipulation in tissue regeneration.