Autophagy's Crucial Role in Oral Tissue Regeneration: A Comprehensive Review

The oral cavity is a unique environment that requires consistent remodeling and regeneration, making autophagy essential for oral tissue regeneration. Additionally, the oral cavity typically hosts a large number of bacterial colonizers, and many oral diseases are caused by bacterial infections and subsequent immune reactions [14]. Numerous studies have reported that autophagy is involved in controlling the burden of infectious agents, including intracellular pathogens, limiting inflammatory pathologies, regulating myeloid/lymphoid cell differentiation, and coordinating multicellular immunity [14]. When combined with the role of autophagy in repairing damaged tissue, it becomes clear that autophagy plays a crucial role in oral tissue regeneration. Despite several studies exploring the role of autophagy in oral diseases and tissue regeneration, there are no systematic reviews on the subject.