Autophagy's Crucial Role in Oral Tissue Regeneration: A Comprehensive Review

The oral cavity is a unique environment that requires constant remodeling and regeneration, making autophagy essential for oral tissue regeneration. Additionally, the oral cavity is home to a large number of bacterial colonizers, which can cause various oral diseases through bacterial infection and subsequent immune reactions. Many studies have demonstrated the role of autophagy in controlling infectious agents, limiting inflammatory pathologies, regulating myeloid/lymphoid cell differentiation, and coordinating multicellular immunity. When combined with the repairment of damaged tissue, it becomes evident that autophagy is closely associated with oral tissue regeneration. Despite numerous studies investigating the role of autophagy in oral diseases and regeneration, no systematic reviews have been conducted on its role in oral tissue regeneration.