The Role of Autophagy in Oral Tissue Regeneration: A Systematic Review

The oral cavity is a unique environment that requires constant remodeling and regeneration, making autophagy crucial for oral tissue regeneration. Additionally, the oral cavity contains a large number of bacterial colonizers, which can cause oral disease through bacterial infection and subsequent immune reaction [14]. Numerous studies have shown that autophagy plays a vital role in controlling the burden of infectious agents, limiting inflammatory pathologies, regulating myeloid/lymphoid cell differentiation, and coordinating multicellular immunity [14]. Given its role in repairing damaged tissue, it is clear that autophagy is closely associated with oral tissue regeneration. Despite many studies exploring the role of autophagy in oral diseases and regeneration, there has yet to be a systematic review on the subject.