Autophagy's Role in Oral Tissue Regeneration: A Systematic Review

The oral cavity is a unique environment that requires constant remodeling and regeneration, making autophagy crucial for oral tissue regeneration. Additionally, the oral cavity hosts a plethora of bacterial colonizers, which can cause various oral diseases through infections and immune reactions. Studies have shown that autophagy plays a crucial role in controlling infectious agents, limiting inflammatory pathologies, regulating myeloid/lymphoid cell differentiation, and coordinating multicellular immunity. Furthermore, autophagy also aids in repairing damaged tissue. Hence, we can conclude that autophagy is closely associated with oral tissue regeneration. Despite several studies exploring the role of autophagy in oral diseases and tissue regeneration, there has been no systematic review on the topic.