EOP and Fluoxetine Mitigate CORT-Induced Hippocampal Neuron Damage in Depressed Mice

As depicted in Figure 2A, a notable reduction in hippocampal neuron density was observed in the CA1 and CA3 regions of the CORT model group compared to the control group. The number of cell layers was significantly reduced, and the cells exhibited a blurred, atrophied, and fragmented appearance, indicating substantial impairment of hippocampal neurons in mice induced by CORT. Notably, treatment with fluoxetine and EOP reversed these pathological alterations, suggesting a protective effect against hippocampal neuron damage in depressed mice. These findings highlight the potential of EOP and fluoxetine as therapeutic agents for mitigating CORT-induced hippocampal neuron damage and its associated behavioral deficits.