what is the IC50 and Ki value of chlorimiprarnine with its each target

Chlorimipramine is a tricyclic antidepressant that acts as a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) and also has anticholinergic and antihistamine properties. It has several targets, including:

1. Serotonin transporter (SERT): The IC50 value of chlorimipramine for SERT inhibition is reported to be in the range of 0.03-0.2 μM.

2. Norepinephrine transporter (NET): The IC50 value of chlorimipramine for NET inhibition is reported to be in the range of 0.4-0.9 μM.

3. Dopamine transporter (DAT): The IC50 value of chlorimipramine for DAT inhibition is reported to be in the range of 6.1-23.5 μM.

4. Muscarinic acetylcholine receptors (mAChRs): The Ki values of chlorimipramine for mAChR subtypes have been reported to be in the range of 0.4-37 μM, with the highest affinity for M1 and M2 subtypes.

5. Histamine receptors (HRs): The Ki values of chlorimipramine for HR subtypes have been reported to be in the range of 0.6-9.5 μM, with the highest affinity for H1 subtype