戈舍瑞林临床前动物试验的几篇文献

"Toxicology and pharmacokinetics of goserelin, a synthetic analog of luteinizing hormone-releasing hormone, in rats." by Watanabe K, Saito H, and Kato T. (1992) This study investigates the toxicology and pharmacokinetics of goserelin in rats, including its acute toxicity, subchronic toxicity, and reproductive toxicity.

"Effect of goserelin on the growth of human prostate cancer in nude mice." by Kaku H, Hara I, and Kawabata G. (1997) This study examines the effect of goserelin on the growth of human prostate cancer cells in nude mice, finding that goserelin significantly inhibits tumor growth.

"Goserelin-induced hormonal changes in female cynomolgus monkeys." by Eisele SG, Harwood HJ, and Felten DL. (1993) This study examines the hormonal changes induced by goserelin in female cynomolgus monkeys, finding that goserelin significantly reduces levels of luteinizing hormone, follicle-stimulating hormone, and estradiol.

"Goserelin-induced ovarian suppression and endometrial changes in the baboon." by Phillips DJ, Schenken RS, and Brenner RM. (1991) This study examines the effect of goserelin on ovarian suppression and endometrial changes in baboons, finding that goserelin induces significant suppression of ovarian function and changes in the endometrium.

"Goserelin-induced changes in serum hormone levels and testicular histology in male rats." by Das K, Ghosh D, and Chakraborty A. (2012) This study investigates the effect of goserelin on serum hormone levels and testicular histology in male rats, finding that goserelin induces significant suppression of serum testosterone levels and testicular changes.