Alzheimer's Disease: Understanding the Mechanisms for Effective Treatment and Prevention

Alzheimer's disease (AD) is a progressive and irreversible brain disorder characterized by memory loss and cognitive decline [1-3]. The severity of dementia in AD patients can range from mild to severe, ultimately leading to complete dependence on others for daily activities [1-3]. Research suggests that changes in the brain associated with AD can occur decades before cognitive symptoms manifest, although the exact cause of these changes remains unknown [1-3]. Understanding the underlying mechanisms that drive AD progression is crucial for developing effective treatments and preventing further cognitive decline [1-3]. Currently, there is no cure for AD [4], emphasizing the urgent need to develop accurate diagnostic tools and novel therapeutic strategies through in-depth mechanistic studies.