SLC7A11 Enhances Endometrial Decidualization Through PPP-Mediated ROS Reduction

SLC7A11 promotes endometrial decidualization by reducing ROS levels via PPP. This process involves the pentose phosphate pathway (PPP), which is a metabolic pathway that generates NADPH and reduces oxidative stress. SLC7A11 plays a crucial role in this process by regulating the transport of cysteine, a key amino acid required for glutathione synthesis. Glutathione is an important antioxidant that protects cells from oxidative damage. By increasing glutathione levels, SLC7A11 helps to reduce ROS levels and promote decidualization.