Multifunctional Nanoparticles for Photothermal Ablation and Immunotherapy of Hepatocellular Carcinoma

The abstract presents a novel multifunctional therapy strategy using mesoporous polydopamine nanoparticles for photothermal ablation and delivery of a repolarizing agent to convert 'M2-like TAMS' to an antitumor phenotype. The addition of nanobubbles enables ultrasound imaging and controlled drug release at the tumor site, facilitating active targeting through chemotaxis after photothermal ablation. The study demonstrates a significant increase in 'M1-like TAMS' and tumor elimination in an orthotopic hepatocellular carcinoma model. This synergistic therapy strategy addresses the deteriorated tumor microenvironment after photothermal ablation, offering a promising approach for clinical combination therapy. The abstract provides a clear and informative summary of the study's purpose, methods, results, and conclusions.