Ultrasound-Stimulated Microbubbles Cavitation Enhances PD-L1 Antibody Therapy for Tumor Treatment

This abstract evaluates the synergistic anti-tumor efficacy and mechanism of perfusion enhancement effect by ultrasound stimulated microbubbles cavitation (USMC) combined with PD-L1 antibody. The study was conducted on tumor-bearing mice divided into four groups: Control, USMC, anti-PD-L1, and USMC+anti-PD-L1. The efficacy of the treatment was assessed by the tumor growth curve and the survival time of mice. The synergistic mechanisms of USMC combined with anti-PD-L1 were explored from four aspects: increased delivery of PD-L1 antibody in tumors, normalization of tumor vessels, improvement of the immune microenvironment, and amelioration of tumor hypoxia. The results showed that the combination therapy achieved greater tumor growth inhibition and longer survival than those of other groups. The synergistic mechanisms of combination therapy included: increased concentration of anti-PD-L1 in tumors, promoted tumor vascular normalization, improved immune microenvironment, and ameliorated tumor hypoxia. Overall, the study suggests that the perfusion enhancement effect produced by USMC could be an effective method for potentiating PD-L1 antibody tumor therapy. The abstract is comprehensive, clearly stating the objectives, methods, and results of the study. Additionally, the abstract provides important insights into the potential mechanisms of the therapy, making it relevant to the field of cancer research.