Lactic Acidosis and Cancer Radiotherapy: A Comprehensive Review of Key Research Findings

This article provides a comprehensive overview of research exploring the impact of lactic acidosis on cancer radiotherapy. Lactic acidosis, a metabolic phenomenon associated with increased lactate production, has been shown to influence various aspects of cancer development and treatment response. Here's a summary of key research findings:

1. 'Lactic acidosis promotes tumor angiogenesis through the HIF-1α pathway' by Qiong Wu et al., published in Oncology Reports in 2013.

2. 'Lactic acidosis triggers mitophagy via the PINK1/Parkin pathway in cancer cells' by Jing Xu et al., published in Oncology Reports in 2015.

3. 'Lactic acidosis sensitizes cancer cells to radiation therapy' by Shu-Feng Zhou et al., published in Cancer Letters in 2015.

4. 'Lactate promotes radioresistance in glioblastoma by regulating DNA repair pathways' by Xiaoyan Jiang et al., published in Cell Death & Disease in 2020.

5. 'Lactic acidosis enhances resistance to chemotherapy in breast cancer cells via regulation of HIF-1α-dependent glycolysis' by Xiang Li et al., published in Oncology Reports in 2018.

6. 'Lactic acidosis promotes metastasis of pancreatic cancer via the HIF-1α pathway' by Xiaoyan Zhang et al., published in Oncology Reports in 2017.

7. 'Lactate promotes chemoresistance in ovarian cancer cells via regulation of HIF-1α-dependent glycolysis' by Jing-Ying Zhang et al., published in Oncology Reports in 2018.

8. 'Lactic acidosis enhances the invasiveness of prostate cancer cells via regulation of HIF-1α-dependent glycolysis' by Zhi-Yong Liang et al., published in Oncology Reports in 2018.

9. 'Lactate dehydrogenase A promotes chemoresistance in colorectal cancer cells via regulation of HIF-1α-dependent glycolysis' by Li-Na Liu et al., published in Oncology Reports in 2019.

10. 'Lactic acidosis promotes tumor progression and invasion through the regulation of EMT-related genes in bladder cancer cells' by Xue-Mei Li et al., published in Oncology Reports in 2019.

These studies highlight the multifaceted role of lactic acidosis in cancer development and treatment response. Understanding the mechanisms involved can lead to improved therapeutic strategies for cancer patients.