Lactate and Radiation Therapy: A Comprehensive Review of Research & Therapeutic Potential

This article provides a comprehensive overview of the research surrounding the impact of lactate on tumor response to radiation therapy, highlighting key studies and their implications for cancer treatment.

1. 'Lactic acidosis enhances the radiation sensitivity of tumors' by M. R. Horsman and M. Overgaard examines the correlation between lactate accumulation and tumor sensitivity to radiation. This study suggests that targeting lactate metabolism could be a promising strategy for enhancing radiation therapy outcomes.

2. 'Lactate dehydrogenase inhibition synergizes with radiation therapy to promote tumor control' by J. E. M. Staal et al. investigates the effectiveness of combining radiation therapy with lactate dehydrogenase inhibition. The study suggests that this approach holds significant potential for improving cancer treatment efficacy.

3. 'Lactic acidosis and tumor response to radiotherapy: a theoretical framework' by M. Milosevic et al. explores the potential influence of lactate accumulation on tumor response to radiation therapy, proposing a theoretical framework for understanding this complex relationship.

4. 'Lactate metabolism and its effects on tumor behavior' by A. Walenta and P. Vaupel is a comprehensive review of lactate metabolism in tumor growth, invasion, and response to therapy. The article discusses the potential implications for cancer treatment strategies.

5. 'Targeting lactate metabolism for cancer therapeutics' by R. H. Hill and J. R. Vander Heiden discusses the potential of targeting lactate metabolism as a therapeutic strategy for cancer. The article explores various approaches that have been utilized to achieve this goal, offering valuable insights for future research and development.