QLU-C10D vs. EQ-5D-5L for Breast Cancer Patients in China: A Comparison of Measurement Properties
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Discussion: The QLU-C10D has been validated for reliability, validity, responsiveness, and sensitivity in the Chinese population with breast cancer. The minimal important differences (MID) are yet to be determined. In this study, the EQ-5D-5L has shown better sensitivity and utility benefits compared to C10D, but they have design differences. Therefore, the choice of which scale to use depends on the specific research or clinical purposes.
In conclusion, there is a clear correlation and similar convergent validity between C10D and 5L. In terms of validating the measurement properties, C10D demonstrates good test-retest reliability and excellent responsiveness in the improvement group. However, in Chinese breast cancer patients, the advantages of using QLU-C10D as a cancer-specific scale are not fully evident, as the RE<1 suggests that EQ-5D-5L is more efficient than QLU-C10D. Moreover, the data in this study suggest that choosing 5L would lead to greater utility gains. Therefore, while QLU-C10D validates good measurement properties as a cancer-specific scale, the choice of QALY calculation should be based on specific circumstances or by comparing multiple scales to determine the optimal solution.
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