MCM6与肿瘤干细胞：关系、机制及临床意义

MCM6 (Minichromosome Maintenance Complex Component 6) 是一种与 DNA 复制和细胞周期调控相关的蛋白质。最近的研究表明，MCM6 在肿瘤干细胞的维持和增殖中发挥重要作用。

MCM6 在肿瘤干细胞中的作用机制可能包括：

• 促进肿瘤干细胞的增殖和自我更新。
• 促进肿瘤干细胞的迁移和侵袭。
• 增强肿瘤干细胞的耐药性。

越来越多的研究表明，MCM6 的表达水平与肿瘤的发生发展、预后密切相关。高表达的 MCM6 与肿瘤的进展、转移和预后不良有关。

参考文献

1. Li J, Li Z, Leng K, et al. Overexpression of MCM6 predicts poor survival in patients with glioma[J]. Human pathology, 2018, 80: 120-126.
2. Wang B, Wang J, Liu Q, et al. MCM6 promotes metastasis of hepatocellular carcinoma via MEK/ERK pathway and serves as a novel serum biomarker for early recurrence[J]. Journal of experimental & clinical cancer research, 2018, 37(1): 10.
3. Chen Z, Huang C, Ma T, et al. MCM6 promotes metastasis of lung adenocarcinoma via EGFR/PI3K/Akt signaling pathway[J]. International journal of oncology, 2018, 53(3): 1067-1078.
4. Sun B, Zhang D, Zhang S, et al. MCM6 promotes metastasis of hepatocellular carcinoma through EGFR/PI3K/Akt/HIF-1α and ERK signaling pathways[J]. Oncology reports, 2017, 38(1): 427-436.
5. Wang L, Guo Z Y, Zhang R, et al. MCM6 promotes metastasis of ovarian cancer via regulating glycolysis[J]. Oncology reports, 2017, 37(4): 2123-2130.