Ultrasensitive Electrochemical MicroRNA Detection with Integrated Amplified Aptasensor and Copper Nanoclusters

This research introduces an integrated amplified aptasensor that combines target amplification and detection in a single step, streamlining analysis and enhancing sensitivity.

The aptasensor incorporates in-situ precise preparation of copper nanoclusters on its surface, effectively amplifying the signal for ultrasensitive detection of microRNA.

The use of aptamers as the recognition element ensures high selectivity and sensitivity towards specific microRNA molecules.

Employing a straightforward and cost-effective electrochemical detection method facilitates real-time monitoring and quantitative analysis of microRNA.

This highly sensitive and specific aptasensor holds significant promise for applications in clinical diagnosis and disease monitoring.