Polystyrene Nanoplastics During Pregnancy Cause Sex-Specific Small Intestinal Toxicity in Offspring via Ferroptosis

This study investigated the sex-specific differences in small intestinal toxicity in offspring of adult mice exposed to polystyrene nanoplastics during pregnancy, and explored the role of ferroptosis. The study found that male offspring exhibited more severe small intestinal damage compared to females, which may be associated with the activation of ferroptosis. This research indicates that polystyrene nanoplastics can induce small intestinal toxicity through the ferroptosis pathway, and that there may be sex-specific differences.