Which Cells Lack HLAs on Their Surface?

D) Mature erythrocytes

Mature erythrocytes, or red blood cells, are the only cells listed that do not contain HLAs (Human Leukocyte Antigens) on their surfaces. HLAs are a group of proteins found on the surface of most cells in the body and play a crucial role in the immune system by helping it to distinguish between self and non-self cells. Mature erythrocytes lack HLAs because they lose their nucleus and other organelles during their development, leaving them with only the essential components for oxygen transport. This absence of HLAs is significant because it prevents the immune system from attacking the erythrocytes.