Early Detection of Gestational Diabetes: Limitations of the OGTT and the Need for Biomarkers

The oral glucose tolerance test (OGTT) is currently the gold standard for diagnosing GDM, and it is usually administered at 24 to 28 weeks of gestation [10]. However, the OGTT is uncomfortable, time-consuming, and poorly reproducible for some pregnant women [11]. Additionally, early-onset GDM (before 24 weeks of gestation) in pregnant women may be missed because the OGTT is routinely performed after 2 weeks. Furthermore, once GDM is confirmed, adverse effects on both the mother and fetus have already occurred, and there is little time to maintain maternal euglycemia without harming the fetus. Therefore, there is an urgent need to identify readily available biomarkers for the early detection of GDM.

Changes:

• 'which were was' -> 'and is usually'
• 'quite poorly reproducible' -> 'poorly reproducible'
• 'would be inevitably be missed' -> 'may be missed'
• 'has have' -> 'have'
• 'readily easily available' -> 'readily available'