Reversal of Sorafenib Resistance in HCT116R Cells by Quercetin: A Mechanistic Investigation

This study investigates the ability of quercetin (QUE) to reverse acquired resistance to sorafenib (SOR) in HCT116R cells. The primary objective is to determine if QUE can overcome the resistance phenotype of these cells and to delve into the molecular mechanisms underlying this process. Understanding the interplay between QUE and SOR resistance in HCT116R cells could offer valuable insights into potential therapeutic strategies for overcoming drug resistance in cancer.