m6A: A Key Regulator of RNA Metabolism and Its Implications in Human Health
m6A (N6-methyladenosine) is a prevalent RNA modification in eukaryotes, which is involved in diverse biological processes, including RNA stability, splicing, translation, and gene expression regulation. m6A modification is dynamically regulated by a complex interplay between methyltransferases, demethylases, and binding proteins. The m6A modification can affect RNA structure, stability, and function through various mechanisms, such as altering RNA-protein interactions, promoting RNA degradation, and influencing translation efficiency. Recently, m6A has been implicated in several human diseases, including cancer, neurological disorders, and viral infections. Therefore, understanding the biological functions and regulatory mechanisms of m6A modification is of great significance for developing novel therapies for these diseases.
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