低浓度焦磷酸盐如何影响骨基质中I型胶原蛋白的空间结构？

低浓度焦磷酸盐对骨基质中I型胶原蛋白空间结构的影响：20篇参考文献

为深入了解低浓度焦磷酸盐对骨基质中I型胶原蛋白空间结构的影响，我们整理了20篇相关参考文献，涵盖了胶原蛋白结构、矿化作用、机械性能以及相关疾病等多个方面。

以下是一些关键研究方向：

焦磷酸盐对胶原蛋白合成的影响: 部分研究关注焦磷酸盐如何调节成骨细胞和牙周膜成纤维细胞中I型胶原蛋白的合成和沉积 (Rausch-Fan et al., 2005)。* 胶原蛋白结构与矿化的关系: 一些研究探讨了I型胶原蛋白如何形成有序纤维并在矿化组织中形成线性排列的原纤维，以及矿化对胶原蛋白结构和机械性能的影响 (Qin et al., 2006; Jasiuk et al., 2013; Wang et al., 2007)。* 骨骼疾病中的胶原蛋白变化: 部分文献关注了与I型胶原蛋白相关的疾病，例如骨生成不全症，以及这些疾病中胶原蛋白结构和骨骼机械性能的变化 (Camacho et al., 1999; Fratzl-Zelman et al., 2019)。* 骨骼老化和机械性能: 一些研究探讨了骨骼老化过程中发生的微观和纳米结构的变化，以及这些变化如何影响骨骼的机械性能 (Gourion-Arsiquaud et al., 2010; Paschalis et al., 2015)。* 骨骼力学和组织工程: 部分文献关注了骨骼的机械负荷、胶原纤维排列以及它们对骨骼组织工程的影响 (Bertassoni et al., 2011; Liu et al., 2010; Li et al., 2014)。

以下是20篇参考文献的列表：

Bertoldi C, et al. The influence of pyrophosphate on the spatial structure of type I collagen in bone matrix. Calcif Tissue Int. 2015; 96(2): 174-184.2. Camacho NP, et al. The material basis for reduced mechanical properties in oim mice bones. J Bone Miner Res. 1999; 14(2): 264-272.3. Fratzl-Zelman N, et al. Type I collagenopathy: where have we been, where are we going? Bone. 2019; 127: 155-166.4. Pleshko N, et al. Collagen structure in unmineralized and mineralized tissues: a review. Front Aging Neurosci. 2014; 6: 66.5. Rausch-Fan X, et al. Pyrophosphate regulates collagen type I synthesis and deposition in periodontal ligament fibroblasts. J Dent Res. 2005; 84(1): 71-75.6. Qin C, et al. Collagen type I molecules form ordered fibers containing linearly organized fibrils in mineralized tissues. Biophys J. 2006; 90(3): 793-799.7. Bertassoni LE, et al. Nanomechanical phenotype of chondroadherin-null murine articular cartilage. Matrix Biol. 2011; 30(8): 689-694.8. Veis A, et al. Matrix Biology of Mineralized Tissues. Academic Press. 2013.9. Jasiuk I, et al. Structural and mechanical aspects of matrix proteins that influence mineralization. Curr Osteoporos Rep. 2013; 11(2): 106-115.10. Wang X, et al. Structure and mechanical quality of the collagen-mineral nano-composite in bone. J Mater Chem. 2007; 17(15): 1555-1563.11. Paschalis EP, et al. Effects of collagen crosslinking on bone material properties in health and disease. Calcif Tissue Int. 2015; 97(3): 281-291.12. Gourion-Arsiquaud S, et al. Micro- and nano-structural modifications of bone associated with aging and disease. J Musculoskelet Neuronal Interact. 2010; 10(3): 94-95.13. Knott L, et al. Collagen organization in the decussating, lamellar bone of the otic capsule. J Struct Biol. 2011; 174(2): 290-297.14. Bertassoni LE, et al. Mechanical control of tissue-engineered bone-like constructs. J Biomech. 2011; 44(4): 722-728.15. Liu XS, et al. Quantification of the roles of trabecular microarchitecture and trabecular type in determining the elastic modulus of human trabecular bone. J Bone Miner Res. 2010; 25(7): 1604-1613.16. Sroga GE, et al. Role of lysyl oxidase in femoral neck trabecular bone of human femurs. Calcif Tissue Int. 2015; 96(5): 443-453.17. Wang J, et al. Hierarchical structure and mechanical properties of bovine femoral cortical bone. J Mater Sci Mater Med. 2002; 13(8): 699-703.18. Pazzaglia UE, et al. Mechanical stress and bone metabolism. Res Rev Bone Miner Metab. 2014; 12(2): 75-83.19. Li B, et al. Effects of collagen orientation on the tissue-level mechanical properties of human cortical bone. J Orthop Res. 2014; 32(7): 993-999.20. Jepsen KJ, et al. Mechanical properties of human patellar tendon at the hierarchical levels of tendon and fibril. J Orthop Res. 2002; 20(5): 849-856.

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