ROR Family: A Promising Target for CSL in Disease Treatment

To identify CSL's disease-related targets, we identified the top 10 CSL target proteins, with the ROR family being the most promising. Docking and drugbank drug target database results showed that RORα, RORβ, and RORγ had high affinity scores, with RORβ having the highest. Although their homology is about 68%, their 3D structures are very similar, with a hydrophobic-LBD domain composed of 9-11 a-helix, stem loop, and β-sheet. RORs have a regulatory role in cancer, autoimmune diseases, and inflammatory responses, with RORα and RORγ being closely associated with the regulation of multiple autoimmune and inflammation-related diseases. RORα is also involved in the development of many malignant tumors, such as liver cancer, breast cancer, glioma, and colorectal cancer. Therefore, targeting RORα and its mediated signaling pathways may become a new avenue of anti-tumor therapy. RORα and RORγ are the more interesting drug targets according to the drug target database.