Autophagy in Oral Tissue Regeneration: Mechanisms, Regulation, and Therapeutic Potential

This review focuses on the role of autophagy in stem cell regulation and oral tissue regeneration. We examine how autophagy helps oral stem cells cope with survival stress and provide an overview of the autophagy machinery in eukaryotes. Additionally, we discuss the ways in which autophagy contributes to different aspects of oral tissue regeneration, including the molecular mechanisms involved. We also explore strategies for regulating autophagy using small molecule drugs, biomaterials, exosomes/RNAs, or other targeted therapies. Finally, we present new perspectives on autophagy manipulation and its potential for enhancing oral tissue regeneration. While the exact mechanism by which autophagy contributes to oral tissue regeneration is not yet fully understood, further research is needed to fully realize its therapeutic potential. This review provides valuable insights into the field of human tissue regeneration and may guide future studies on autophagy and tissue regeneration in the oral cavity and beyond.