Autophagy and Oral Tissue Regeneration: A Comprehensive Review

This review focuses on the role of autophagy in regulating stem cells and promoting oral tissue regeneration. We discuss how autophagy helps oral stem cells overcome survival stress and provide an overview of the autophagy machinery in eukaryotic cells. In addition, we explore how autophagy contributes to different aspects of oral tissue regeneration, providing insights into the molecular mechanisms involved. We also discuss the potential of small molecule drugs, biomaterials, exosomes/RNAs, and other specific treatments for regulating autophagy in the context of oral tissue regeneration. Finally, we offer new perspectives on autophagy manipulation and its potential applications in oral tissue regeneration. However, the exact mechanisms underlying autophagy's role in oral tissue regeneration are not yet fully understood, and further studies are needed to advance therapeutic strategies. This review provides a valuable resource for researchers interested in autophagy and tissue regeneration, and may pave the way for further investigations into the potential of autophagy in promoting oral tissue and other tissue regeneration.