Autophagy and Oral Tissue Regeneration: A Systematic Review

The oral cavity is a unique environment that requires consistently remodeling and generation, which means autophagy is required in oral tissue regeneration. What’s more, the oral cavity usually contains a large number of bacterial colonizers. Many oral diseases are caused by bacterial infection and subsequent immune reaction [14]. Many studies reported that autophagy involved in controlling the burden of infectious agents (including some intracellular pathogens), limiting inflammatory pathologies, regulating myeloid/lymphoid cell differentiation, and coordinating multicellular immunity [14]. Combined with the role of autophagy in the repairment of damaged tissue, we may conclude that autophagy has a close association with oral tissue regeneration. Although many studies have explored the role of autophagy in oral diseases and oral tissue regeneration, there have been no systematic reviews on the role of autophagy in oral tissue regeneration.

Therefore, a systematic review is needed to summarize the current understanding of the role of autophagy in oral tissue regeneration. This review will provide a comprehensive overview of the involvement of autophagy in the regeneration of oral tissue, including the regulation of inflammation, cell differentiation, and tissue repairment. Moreover, it will also discuss the potential therapeutic strategies that target autophagy for the treatment of oral diseases and promotion of oral tissue regeneration. By clarifying the relationship between autophagy and oral tissue regeneration, this review may contribute to the development of novel therapeutic approaches for oral diseases and tissue regeneration.