Autophagy's Crucial Role in Oral Tissue Regeneration: A Comprehensive Review

The oral cavity is a unique environment that requires consistent remodeling and regeneration, making autophagy crucial in oral tissue regeneration. Furthermore, the oral cavity is home to a multitude of bacterial colonizers, often causing oral diseases through bacterial infection and subsequent immune reactions. Studies have shown that autophagy plays a vital role in controlling infectious agents, regulating myeloid/lymphoid cell differentiation, limiting inflammatory pathologies and coordinating multicellular immunity. Combined with autophagy's role in repairing damaged tissue, it is clear that autophagy is closely associated with oral tissue regeneration. Despite numerous studies examining autophagy's role in oral diseases and oral tissue regeneration, there have been no systematic reviews on the subject.