Ketamine's Rapid Antidepressant Effects and Potential as a Novel Treatment: Neurobiological Mechanisms in the CLACaMKIIα-mPFC Circuit

Conclusion: The above results indicate that ketamine has a rapid antidepressant effect, and its neurobiological mechanism may be through the disinhibition of CLACaMKIIα neurons → mPFC neuron loop, suggesting the potential prospect of ketamine as a rapid antidepressant drug. This discovery may provide new ideas for the development of more effective antidepressant drugs in the future.