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\section*{Conclusion} Overall, this article puts forward a conceptual and practical framework (Figure~\ref{fig:88833}) of a general intermolecular binding affinity calculator (GIBAC \cite{Li2022GIBAC}). Only a GIBAC with adequate accuracy, precision, and efficiency is able to create a paradigm shift \cite{Subramaniam2022} from structure-based molecular generation to a search engine for drug discovery & design and find its practical application in the pharmaceutical industry \cite{Gupta_2021, Bonvin_2021}. The time is now ripe for the construction of such a GIBAC to be listed on the agenda of the drug R&D community, including in particular structural biologists and biophysicists, medicinal and computational chemists, drug discoverers & designers, and algorithm designers, in light of