From the Treg suppression results nTregs could suppress CD4+T and CD8+ T cell proliferation in the DMSO group For CD4+ T proliferation PTC-0432253 promoted the suppression at all ratios tested PTC-043

This suggests that both PTC-0432253 and PTC-0432366 can enhance the production of IFN-gamma when Tregs are present. However, it is important to note that these compounds do not have any effect on T cells in the absence of Tregs.