Genetic variations occur in infectious diseases non-communicable diseases and also rare disease such as spinal muscular atrophyFor instance The emergence of resistance to antibody therapies targeting

Genetic variations play a crucial role in various diseases, including infectious diseases, non-communicable diseases, and rare conditions like spinal muscular atrophy. One area where genetic variations have posed a significant challenge is cancer treatment, specifically in the emergence of resistance to antibody therapies targeting proteins like EGFR and PD-1/PD-L1. To address this issue, the development of a general intermolecular binding affinity calculator (GIBAC) could be a promising approach. GIBAC would allow researchers to predict the binding affinity between therapeutic antibodies and their target proteins, taking into account genetic variations that may influence the effectiveness of these treatments. By accurately assessing intermolecular interactions, GIBAC could aid in the design of more personalized and effective therapies, ultimately improving patient outcomes in cancer treatment and beyond.