继续帮我润色、优化、找出语法错误写成符合英文习惯的表达方式:To identify independent prognosis factor associating with PMP first of all univariate analyses with the Cox proportional hazards model was used to examine the association
To identify independent prognostic factors associated with PMP, we first used univariate analyses with the Cox proportional hazards model to examine the association between PFS and OS, as well as clinical characteristics such as phenotypes and genotypes. The factors correlated with PFS and OS, including age, gender, PCI, Completeness of cytoreduction (CC), pathological grade, lymph node involvement, HRD, TMB, NMF Cluster associated mutational signatures, and mutational status of nine genes (GNAS, KRAS, TTN, TP53, MUC16, TGFBR2, SMAD4, SMAD2, and ATM), were used as covariates. The results revealed that OS was significantly worse in males (HR: 3.946, CI95%: 1.047-14.880, p = 0.043), those with TMB>1, TP53 mutation (p = 0.013), NMF cluster 1, MUC16 mutation (p = 0.010), and SMAD4 mutant group (p = 0.025), compared to females, those with TMB<1, TP53 wild type, NMF other clusters, MUC16 wild type, and SMAD4 wild type group.
Next, we performed Cox proportional hazards multivariate modeling analysis, considering gender, TMB, NMF cluster, and mutation status of TP53, MUC16, and SMAD4 as candidate predictors. Through this analysis, we further identified that only gender (p=0.049), NMF cluster (p = ), TP53 (p=0.006), and MUC16 (p=0.021) remained as independent predictors of OS
原文地址: https://www.cveoy.top/t/topic/irEp 著作权归作者所有。请勿转载和采集!