帮我翻译润色一下下一段画开发了一种通过铑催化邻炔基苯基异硫氰酸酯和氟化银的串联N-三氟甲基化环化反应以及铜催化邻炔基苯胺与三氟甲硫银、碘化钾、氟化银一锅反应来构建2-取代-N-三氟甲基吲哚化合物的方法。这两种方法反应条件温和且操作简单并可耐受各种官能团。该反应是可扩展的可用于药物的后修饰。
A method for the construction of 2-substituted-N-trifluoromethyl indole compounds has been developed through a tandem N-trifluoromethylation/cyclization reaction of ortho-ethynyl phenyl isothiocyanates with silver fluoride catalyzed by rhodium, as well as a one-pot reaction of ortho-ethynyl anilines with trifluoromethylthio silver, potassium iodide, and silver fluoride catalyzed by copper. Both methods offer mild reaction conditions, simple operation, and tolerance towards various functional groups. The reaction is scalable and can be used for the post-modification of pharmaceuticals
原文地址: https://www.cveoy.top/t/topic/ijdu 著作权归作者所有。请勿转载和采集!