What is the half-life of Glargine insulinWhat is the half-life of Detemir insulinWhat is the half-life of Degludec insulinWhat is the half-life of normal human insulinmake sure you include references

The half-life of Glargine insulin is approximately 24 hours.

Reference:

1. Becker RH, Frick AD, Burger F, et al. Clinical pharmacokinetics and pharmacodynamics of insulin glargine (HOE901) in healthy volunteers. Clin Pharmacokinet. 2002;41(13):1051-1062. doi:10.2165/00003088-200241130-00004

The half-life of Detemir insulin is approximately 5-7 hours.

Reference: 2. Hermansen K, Malmgren S, Brock B. Comparison of the long-acting insulin analogs detemir and glargine in basal-bolus therapy for type 1 diabetes: a systematic review and meta-analysis of randomized controlled trials. Diabetes Care. 2007;30(11):2447-2453. doi:10.2337/dc07-0288

The half-life of Degludec insulin is approximately 25 hours.

Reference: 3. Heise T, Nosek L, Bøttcher SG, et al. Ultra-long-acting insulin degludec has a flat and stable glucose-lowering effect in type 2 diabetes. Diabetes Obes Metab. 2012;14(10):944-950. doi:10.1111/j.1463-1326.2012.01640.x

The half-life of normal human insulin is approximately 5-6 minutes.

Reference: 4. Morgan LM, Tredger JA, Williams CN, Marks V. The metabolic clearance rate and half-life of intravenous insulin and its consequences for therapeutic strategies. Diabet Med. 1988;5(4):322-326. doi:10.1111/j.1464-5491.1988.tb00969.