翻译：摘要 由于口服和注射给药存在着胃肠道反应或吸收率低等局限透皮给药途径吸引了越来越多的研究。生物材料的迅猛发展为透皮给药创造了更多的可能性。本文的研究目标是基于透皮给药生物材料的发展建立各类用生物材料制成的透皮给药策略框架。本文主要介绍了新兴的生物材料及基于生物材料的透皮给药系统尤其是微针给药。通过查阅近年来基于生物材料的透皮给药相关论文及上市产品我们得到了不同透皮给药剂型材料的详细信息及其独

Abstract: Due to the limitations of gastrointestinal reactions or low absorption rates in oral and injection administration, transdermal drug delivery has attracted more and more attention. The rapid development of biomaterials has created more possibilities for transdermal drug delivery. The aim of this study is to establish a framework of various transdermal drug delivery strategies made from biomaterials based on the development of transdermal drug delivery biomaterials. This article mainly introduces emerging biomaterials and transdermal drug delivery systems based on biomaterials, especially microneedle drug delivery. By reviewing relevant papers and marketed products related to biomaterial-based transdermal drug delivery in recent years, we obtained detailed information on different transdermal drug delivery materials and their unique advantages. This helps readers understand the diverse therapeutic options of biomaterial-based transdermal drug delivery systems, their significant advantages over oral and injection administration routes, and insights into the recent development of products in this industry, providing new ideas and strategies for the development and clinical treatment of transdermal drug delivery products. We will introduce the following viewpoints: (1) Introduction of transdermal drug delivery systems; (2) Brief introduction of microneedle concept; (3) Research progress of biomaterial-based transdermal drug delivery strategies; and finally, (4) The potential and challenges of biomaterial-based transdermal drug delivery.

Keywords: Biomaterials; Transdermal drug delivery systems; Microneedles; Clinical treatment; Drug delivery