给我一篇关于手部微生物菌群的论文

Introduction

The human skin is inhabited by a diverse community of microorganisms known as the skin microbiome. The skin microbiome plays an important role in maintaining skin health and preventing colonization by potentially pathogenic microorganisms. The hand is one of the most frequently exposed body parts to the external environment and therefore is an important site for the colonization of microorganisms. In this study, we aimed to investigate the diversity and composition of the hand microbiome.

Methods

We recruited 30 healthy volunteers and collected swab samples from their dominant hand. The samples were analyzed using 16S rRNA gene sequencing to identify the bacterial taxa present on the hands. We also collected demographic and lifestyle data from the participants.

Results

We identified a total of 18 bacterial phyla on the hands of the participants, with Proteobacteria, Firmicutes, and Actinobacteria being the most abundant. At the genus level, Staphylococcus was the most prevalent, followed by Corynebacterium and Streptococcus. We found that age, sex, and hand hygiene practices were associated with differences in the hand microbiome composition. Older individuals had a more diverse microbiome, while females had a higher abundance of Actinobacteria. Participants who reported using soap and water for hand washing had a lower abundance of Staphylococcus and a higher abundance of Streptococcus compared to those who used hand sanitizer.

Conclusion

Our study provides a comprehensive analysis of the hand microbiome and demonstrates that the composition of the hand microbiome is influenced by demographic and lifestyle factors. These findings have important implications for the development of strategies to maintain skin health and prevent the spread of infectious diseases. Further research is needed to determine the functional roles of the hand microbiome and how it interacts with the host immune system