Elongation of very long chain fatty acids protein 6

Elongation of very long chain fatty acids protein 6 (ELOVL6) is an enzyme that is involved in the synthesis of long-chain fatty acids. It catalyzes the elongation of fatty acids by adding two carbon units to the acyl-CoA substrate.

ELOVL6 is primarily expressed in the liver, where it plays a crucial role in the production of long-chain fatty acids that are important for energy storage and membrane structure. It is also expressed in other tissues, such as adipose tissue and the brain, but to a lesser extent.

Mutations in the ELOVL6 gene have been associated with various metabolic disorders, including obesity, insulin resistance, and non-alcoholic fatty liver disease. These mutations can lead to impaired fatty acid metabolism and dysregulation of lipid homeostasis.

Understanding the function and regulation of ELOVL6 is important for studying lipid metabolism and its implications in various metabolic diseases.