改写下列句子:In conclusion we demonstrated that Aβ1-42 treatment significantly downregulated miR-137-5p and upregulated USP30 in cortical neurons and SH-SY5Y cells Furthermore miR-137-5p attenuated Aβ1-42 i
To sum up, our study showed that Aβ1-42 treatment led to a notable decrease in miR-137-5p and an increase in USP30 in cortical neurons and SH-SY5Y cells. Additionally, we found that miR-137-5p played a role in reducing Aβ1-42-induced neurotoxicity by targeting USP30 in SH-SY5Y cells. These findings provide insights into the molecular mechanism of miR-137 in Aβ-induced neurotoxicity and suggest that miR-137 could be a promising therapeutic target for Alzheimer's disease treatment.
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