brief summaryIn the present study we proposed the reduction ratio of TTV andexplored its clinical value in the evaluation of conversion outcome andlong-term survival in patients with initially unresec

In this study, the researchers investigated the reduction ratio of total tumor volume (TTV) as a potential prognostic indicator in patients with initially unresectable colorectal liver metastases (CRLM) receiving first-line systemic treatment. They found that a significant reduction in TTV was associated with a favorable conversion outcome and long-term survival. The combination of the reduction ratio of TTV and RECIST classification showed prognostic discriminatory power in patients with partial response (PR) and stable disease (SD). The reduction ratio of TTV was also found to be influenced by treatment regimen and genotype status. The researchers concluded that the reduction ratio of TTV could be used to determine optimal candidates for surgical resection after first-line chemotherapy in CRLM patients. However, the study had some limitations, including its retrospective nature and the need for further validation in larger prospective cohorts. Additionally, the study did not evaluate the change in TTV during first-line treatment, which could be explored in future studies.