Brief summary of the following articleIt is well known that tumor invasion and the number ofmetastatic lymph nodes are two vital pathological parametersthat can be applied to identify the recurrence r

This article discusses the prognostic value of lymphovascular invasion (LVI) and perineural invasion (PNI) in stage III colon cancer. The study found that LVI and PNI are important pathological factors for predicting 3-year disease-free survival (DFS) in patients with stage III colorectal cancer. The presence of LVI and PNI was associated with advanced N stage and indicated an adverse clinical course. The study also found that LVI had a better predictive value for the efficacy of adjuvant chemotherapy compared to PNI. The presence of both LVI and PNI was associated with the worst 3-year DFS and overall survival rates. The study suggests that LVI and PNI are related to aggressive tumor features and understanding the underlying mechanisms may help develop therapeutic strategies to inhibit metastatic spread. The study also suggests that the presence of LVI can be used to guide individual management of adjuvant chemotherapy for stage III colon cancer. However, the study has limitations, including its retrospective nature and a limited number of patients, and further studies are needed to validate these findings. Additionally, the study did not include tumor molecular markers, which could provide further risk stratification