Establishment of DDP-Resistant Cell Lines: A2780/DDP and SKOV3/DDP

The MTT experiment results revealed that the IC50 value of the A2780/DDP cell line (61.71±4.10 μM) was significantly higher than that of the wild-type A2780 cell line (10.94 ± 1.27 μM). Similarly, the IC50 value of the SKOV3/DDP cell line was also significantly increased compared to the wild-type SKOV3 cell line, from 9.94 ± 0.95 μM to 44.89 ± 3.22 μM, indicating the successful establishment of DDP-resistant cell lines.