Insulin Binding: Receptor Interactions, Dimerization, and Hexamer Formation

Insulin binds to the insulin receptor (INSR), but it does not bind to the insulin-like growth factor 1 receptor (IGF1R) or the insulin-like growth factor 2 receptor (IGF2R).

Insulin does not form dimers. It is a monomeric protein consisting of two peptide chains held together by disulfide bonds.

Insulin can form hexamers under certain conditions, such as in the presence of zinc ions. These hexamers are the storage form of insulin in the pancreas.

Insulin can also bind to other molecules, such as insulin-like growth factors (IGFs) and insulin-like growth factor binding proteins (IGFBPs), which regulate its activity and distribution in the body.

Here are some references in BibTeX format:

1. Insulin receptor: https://pubmed.ncbi.nlm.nih.gov/28333380/
2. Insulin-like growth factor 1 receptor: https://pubmed.ncbi.nlm.nih.gov/25355687/
3. Insulin-like growth factor 2 receptor: https://pubmed.ncbi.nlm.nih.gov/19575547/
4. Insulin dimerization: https://pubmed.ncbi.nlm.nih.gov/12034849/
5. Insulin hexamer formation: https://pubmed.ncbi.nlm.nih.gov/17924679/
6. Insulin binding to other molecules: https://pubmed.ncbi.nlm.nih.gov/12800489/

Please note that the actual content of the references may vary, and it is recommended to retrieve the full articles for accurate information.