Scopolamine Impairs Spatial Learning in Mice: Evidence from Morris Water Maze

During the five-day acquisition testing period (day 24–28), control group mice displayed a gradual decrease in latencies when locating the concealed platform. This finding indicates that repeated training had a positive effect on their spatial learning abilities. In contrast, model mice treated with scopolamine showed significantly higher latencies (p < 0.05) compared to the control group. These results suggest that scopolamine impairs spatial learning in mice, potentially by interfering with the mechanisms involved in memory formation and retrieval.