帮忙修改以下英文Conclusions Anti-angiogenesis role of TGFβ is abrogated by a novel HIF1α-miR145-Smad23-TSP1 axis in endothelial cells which highlights hypoxia microenvironment as a key factor for the tumor to

Conclusions: Our findings reveal that the anti-angiogenic effect of TGFβ is counteracted by a novel HIF1α-miR145-Smad2/3-TSP1 pathway in endothelial cells, emphasizing the significance of hypoxia in enabling tumors to evade TGFβ-mediated anti-angiogenic control.

Lay summary: Our research has identified how the function of transforming growth factor β in normal angiogenesis and hepatocellular carcinoma (HCC) angiogenesis can be altered by the hypoxic microenvironment. We have discovered the molecular mechanisms underlying these processes, offering new insights into the intricate regulatory network of transforming growth factor β in HCC angiogenesis, with potential implications for personalized medicine