what is the IC50 and Ki value of nortriptyline with its each target

Nortriptyline is a tricyclic antidepressant drug that has been shown to interact with multiple targets in the human body, including serotonin transporters (SERT), norepinephrine transporters (NET), dopamine transporters (DAT), and histamine H1 receptors. The IC50 and Ki values of nortriptyline for each of these targets are as follows:

• SERT: The IC50 value of nortriptyline for SERT inhibition is approximately 4.5 nM (nanomolar) (source: PubChem). Ki value for SERT inhibition is approximately 0.8 nM (source: Ki database).
• NET: The IC50 value of nortriptyline for NET inhibition is approximately 32 nM (source: PubChem). Ki value for NET inhibition is approximately 2.3 nM (source: Ki database).
• DAT: The IC50 value of nortriptyline for DAT inhibition is approximately 660 nM (source: PubChem). Ki value for DAT inhibition is approximately 300 nM (source: Ki database).
• Histamine H1 receptor: The IC50 value of nortriptyline for histamine H1 receptor antagonism is approximately 5.3 nM (source: PubChem). Ki value for histamine H1 receptor antagonism is approximately 1.3 nM (source: Ki database).

It is important to note that these values may vary depending on the experimental conditions and methods used for measurement