what is the IC50 and Ki value of maprotiline with its each target

Maprotiline is a tricyclic antidepressant drug that acts as a norepinephrine reuptake inhibitor (NRI) and a serotonin receptor antagonist. The IC50 and Ki values of maprotiline for its targets are as follows:

1. Norepinephrine transporter (NET) - IC50 = 10.8 nM
2. Serotonin transporter (SERT) - IC50 = 1,117 nM
3. Alpha-1 adrenergic receptor - Ki = 68 nM
4. 5-HT2A serotonin receptor - Ki = 2,008 nM
5. Muscarinic acetylcholine receptor M1 - Ki = 2,236 nM

Note: Values may vary depending on the source of information and the method of measurement