what is the IC50 and Ki value of clomipramine with its each target

Clomipramine is a tricyclic antidepressant that has multiple targets. The IC50 and Ki values of clomipramine with its each target are as follows:

1. Serotonin transporter (SERT): Clomipramine has an IC50 of 0.14 nM and a Ki value of 0.07 nM for SERT.

2. Norepinephrine transporter (NET): Clomipramine has an IC50 of 2.3 nM and a Ki value of 0.65 nM for NET.

3. Dopamine transporter (DAT): Clomipramine has an IC50 of 4.1 nM and a Ki value of 0.47 nM for DAT.

4. Muscarinic acetylcholine receptors (M1-5): Clomipramine has a Ki value of 30 nM for M1, 0.35 nM for M2, 170 nM for M3, 19 nM for M4, and 140 nM for M5.

5. α1-adrenergic receptors: Clomipramine has a Ki value of 4.3 nM for α1A, 32 nM for α1B, and 7.4 nM for α1D.

6. H1 histamine receptors: Clomipramine has a Ki value of 3.4 nM for H1 receptors.

7. Sigma receptors (σ1 and σ2): Clomipramine has a Ki value of 12 nM for σ1 receptors and 170 nM for σ2 receptors.

It is important to note that the IC50 and Ki values may vary depending on the experimental conditions and methods used to measure them